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Scientist, Immunology and T cell Gene Editing

San Francisco, CA 94105

Employment Type: Direct Hire Position: Biotechnology/Pharmaceuticals Job Number: 6000868

Job Description

ABOUT THE ROLE:

  • Develop and optimize protocols for T cell gene editing, including: megaTAL delivery methods, culture conditions, scale up, and multiplexing
  • Characterize genetically modified primary T lymphocytes using standard immunological assays including flow cytometry
  • Develop and perform immune cell activation, cytotoxicity, and other cellular and ELISA-based assays to evaluate gene editing approaches that improve the efficacy of CAR and TCR based T cell therapeutics in vitro and in vivo
  • Maintain an electronic lab notebook and contribute to support documentation when necessary
  • Contribute to experimental design and project direction
  • Provide critical lab support while working in a collaborative team environment
  • Compile and present research data to functional teams

 

 

Job Requirements

  • BS in immunology, cell biology or related discipline with 8 years of experience or MS with 2-4 years experience, PhD 0-2 years experience (industry experience preferred)
  • Good understanding of immunology and cancer biology
  • Experience in primary human immune cell isolation techniques and mammalian cell culture, including cell culture of primary human T lymphocytes
  • Experience working in in vitro immunology studies and functional T cell assay development using techniques such as multi-color flow cytometry, Luminex, ELISA and cytotoxicity assays is required
  • Experience with gene editing or lentiviral vector transduction a plus
  • Experience with standard molecular biology techniques, including but not limited to, PCR, RT-PCR, qPCR, Westerns, and RNA in vitro transcription a plus
  • Excellent computer skills, including experience with Microsoft Excel and PowerPoint, Graphpad Prism, DNA software tools (e.g. Geneious), and FlowJo
  • Ability to quickly adapt to new research areas and implement new techniques independently
  • Scientifically rigorous, highly organized, and with significant attention to detail
  • Strong oral and written communication skills

Meet Your Recruiter

Heather Keller
Vice President of Operations

Heather has over twelve years of pharmaceutical and medical device staffing and consulting experience gained from roles with global staffing and professional services firms. Heather's focus is on strengthening client relationships to become a trusted partner and talent advisor. Heather’s expertise includes developing creative and efficient sourcing and recruitment processes, uncovering channels of top talent for hard to fill roles and optimizing organizational design in order to deliver top talent to clients. Prior to joining the staffing industry, she conducted biomedical research and conducted drug target validation studies. Heather has a bachelor of science in Biological Sciences from UC Davis with an emphasis in Neurobiology, Physiology and Behavior.

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